DISC
Enhancing Gen3 for Clinical Trial Time Series Analytics and Data Discovery: A Data Commons Framework for NIH Clinical Trials
This work presents a framework for enhancing Gen3, an open-source data commons platform, with temporal visualization capabilities for clinical trial research. We describe the technical implementation of cloud-native architecture and…
Read MoreBreaking Digital Health Barriers Through a Large Language Model-Based Tool for Automated Observational Medical Outcomes Partnership Mapping: Development and Validation Study
Background: The integration of diverse clinical data sources requires standardization through models such as Observational Medical Outcomes Partnership (OMOP). However, mapping data elements to OMOP concepts demands significant technical expertise…
Read MoreConnecting Chronic Pain and Opioid Use Disorder Clinical Trials Through Data Harmonization: Wake Forest IMPOWR Dissemination, Education, and Coordination Center (IDEA-CC)
The National Institutes of Health (NIH) has developed the NIH HEAL Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR) network to address the interconnected nature of chronic…
Read MoreNotable Concerns in Methodology and Conclusions of the Wang et al. Meta-Analysis in BMJ by the American Academy of Pain Medicine
Cost Disparities Between Pain and Opioid Use Disorder Formulations of Buprenorphine in US Health Care System: A Cross-Sectional Analysis
Background: Buprenorphine offers unique therapeutic benefits in both pain management and addiction medicine through its partial μ-opioid agonist and κ-opioid antagonist properties, providing effective analgesia with reduced abuse potential and…
Read MoreMedicaid Coverage Policy Variations for Chronic Pain and Opioid Use Disorder Treatment
Importance: Co-occurring chronic pain and opioid use disorder (OUD) are associated with a high disease burden for the patient, requiring comprehensive treatment approaches, yet Medicaid benefit structures for evidence-based therapies…
Read MoreAdapting the Open-Source Gen3 Platform and Kubernetes for the NIH HEAL IMPOWR and MIRHIQL Clinical Trial Data Commons: Customization, Cloud Transition, and Optimization
Objective: This study aims to provide the decision-making framework, strategies, and software used to successfully deploy the first combined chronic pain and opioid use data clinical trial data commons using…
Read MoreBuilding Community Through Data: The Value of a Researcher Driven Open Science Ecosystem
Automated Multi-Instance REDCap Data Synchronization for NIH Clinical Trial Networks
Objectives: The main goal is to develop an automated process for connecting Research Electronic Data Capture (REDCap) instances in a clinical trial network to allow for deidentified transfer of research…
Read MoreThe NIH HEAL Pain Common Data Elements (CDE): A Great Start but a Long Way to the Finish Line
Background: The National Institutes of Health (NIH) Pain Common Data Elements (CDEs) provide a standardized framework for pain research, but their implementation and interpretation present challenges. Objectives: To review the…
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